Research Highlights

Tissue & Organ Function-on-a-Chip

Related Articles:


Haewon Seo, Jaejung Son, Je-Kyun Park, "Controlled 3D co-culture of beta cells and endothelial cells in a micropatterned collagen sheet for reproducible construction of an improved pancreatic pseudo-tissue," APL Bioeng., 4 (4), 046103 (2020).   OPEN ACCESS
The first two authors contributed equally to this work.


Minkyung Cho, Je-Kyun Park, "Fabrication of a perfusable 3D in vitro artery-mimicking multichannel system for artery disease models," ACS Biomater. Sci. Eng., 6 (9), 5326-5336 (2020). 
External link
Supporting Info. (pdf, 541 KB) 


Juhwan Park, Hwisoo Kim, Je-Kyun Park, "Microfluidic channel-integrated hanging drop array chip operated by pushbuttons for spheroid culture and analysis ," Analyst, 145 (21), 6974-6980 (2020).  
External link External link
Supporting Info. (pdf, 349 KB), Movie 1 (MP4, 273 KB)


Young Lee, Soo Jee Kim, Je-Kyun Park, "Chips-on-a-plate device for monitoring cellular migration in a microchannel-based intestinal follicle-associated epithelium model," Biomicrofluidics, 13 (6), 064127 (2019).  
External link Supporting Info. (DOCX, 273KB)


Young Lee, Gihyun Lee, Minkyung Cho, Je-Kyun Park, "Design criteria and standardization of a microfluidic cell culture system for investigating cellular migration," J. Micromech. Microeng., 29 (4), 043003 (2019).  
External link Invited Topical Review 


Jaejung Son, Min Seo Bang, Je-Kyun Park, "Hand-maneuverable collagen sheet with micropatterns for 3D modular tissue engineering," ACS Biomater. Sci. Eng., 5 (1), 339-345 (2019).
External link Supporting Info. (pdf, 828 KB)


Hwisoo Kim, Chang Hyun Cho, Je-Kyun Park, "High-throughput culture and embedment of spheroid array using droplet contact-based spheroid transfer," Biomicrofluidics, 12 (4), 044109 (2018).
External link Supporting Info. (doc, 3 MB and video avi, 3 MB)
External link Featured Article (July 1, 2018)
External link Highlighted in AIP Scilight (Simple devices enhance the embedment of spheroids into hydrogel arrays --- by Mary Alexandra Agner)



Young Lee, Je-Kyun Park, "Microfabricated cell culture system for the live cell observation of the multilayered proliferation of undifferentiated HT-29 cells," BioChip J.11 (4), 308-315 (2017).


Chae Yun Bae, Jaejung Son, Hail Kim, Je-Kyun Park, "Demonstration of interposed modular hydrogel sheet for multicellular analysis in a microfluidic assembly platform," Sci. Rep., 7, 1289 (2017).      OPEN ACCESS  
External link Supporting Info. (pdf, 1.91 MB)


Chang Hyun Cho, Seyong Kwon, Je-Kyun Park, "Assembly of hydrogel units for 3D microenvironment in a poly(dimethylsiloxane) channel," Micro Nano Syst. Lett., 5, 2 (2017).    OPEN ACCESS  


Jaejung Son, Chae Yun Bae, Je-Kyun Park, "Construction of modular hydrogel sheets for micropatterned macro-scaled 3D cellular architecture," J. Vis. Exp., 107, e53475, doi:10.3791/53475 (2016).  


Commentary in Biotechnology Journal: Stackable micropatterned hydrogels for analysis of thick tissues in vitro by Bobak Mosadegh

External link See accompanying article by Son et al. DOI 10.1002/biot.201500384


Jaejung Son, Chae Yun Bae, Je-Kyun Park, "Freestanding stacked mesh-like hydrogel sheets enable the creation of complex macroscale cellular scaffolds," Biotechnol. J., 11 (4), 585-591 (2016).    
External link Supporting Info. (zip, 6661 KB)  

External link See accompanying commentary by Bobak Mosadegh DOI 10.1002/biot.201500562 


Chae Yun Bae, Moon-kyung Min, Hail Kim, Je-Kyun Park, "Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters," Lab Chip, 14 (13), 2183-2190 (2014).  


Wonhye Lee, Chae Yun Bae, Seyong Kwon, Jaejung Son, Jinho Kim, Yong Jeong, Seung-Schik Yoo, Je-Kyun Park, "Cellular hydrogel biopaper for patterned 3D cell culture and modular tissue reconstruction," Adv. Healthcare Mater.1 (5), 635-639 (2012).  
External link Supporting Info. (pdf, 366 KB; movie 1, 1315 KB)


Featured on the Inside Front Cover, Tissue Reconstruction (Adv. Healthcare Mater. 5/2012) (page 530)


Wonhye Lee, Jaejung Son, Seung-Schik Yoo, Je-Kyun Park, "Facile and biocompatible fabrication of chemically sol-gel transitional hydrogel free-standing microarchitectures," Biomacromolecules, 12 (1), 14-18 (2011).    
External link Supporting Info. (pdf, 828 KB)



Joon Seok Lee, Eujin Um, Je-Kyun Park, Chan Beum Park, "Microfluidic self-assembly of insulin monomers into amyloid fibrils on a solid surface," Langmuir, 24 (14), 7068-7071 (2008).
External link Supporting Info. (pdf, 3.32 MB)