Research Highlights

3D Bio-Printing Technologies

Related Articles:

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Jongho Park, Gihyun Lee, Je-Kyun Park, "Functional assessment of a bioprinted immuno-mimetic Peyer’s patch recapitulating gut-associated lymphoid tissue," Adv. Healthcare Mater., 14 (1) 2402722 (2025).
External link  Supporting Info.:  Word (docx, 1.4 MB), Video S1 (mp4, 7.7 MB)
External link  The first two authors contributed equally to this work.

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Gihyun Lee, Soo Jee Kim, Yejin Choi, Jongho Park, Je-Kyun Park, "Bioprinting of a multi-composition array to mimic intra-tumor heterogeneity of glioblastoma for drug evaluation," Microsyst. Nanoeng., 10, 186 (2024). OPEN ACCESS 
External link
Supporting Info. (pdf, 457 KB)

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Gihyun Lee, Soo Jee Kim, Je-Kyun Park, "Bioprinted multi-composition array mimicking tumor microenvironments to evaluate drug efficacy with multivariable analysis," Adv. Healthcare Mater., 13 (22), 2303716 (2024).  OPEN ACCESS
External link Supporting Info.: Word (docx, 4.9 MB), Video S1 (mp4, 3.3 MB), and Video S2 (mp4, 663.4 KB)  
External link Hot Topic: Microfluidics
External link
Hot Topic: Tumors and Cancer

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Soo Jee Kim, Gihyun Lee, Je-Kyun Park, "Hybrid biofabrication of heterogeneous 3D constructs using low-viscosity bioinks," ACS Appl. Mater. Inter., 15 (35), 41247-41257 (2023).
External link Supporting Info. (pdf, Movie S1, Movie S2, and Movie S3)  

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Gihyun Lee, Soo Jee Kim, Je-Kyun Park, "Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip," Lab Chip, 23 (18), 4079-4091 (2023).
External link Supporting Info. (pdf, Video S1)  

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Gihyun Lee, Soo Jee Kim, Je-Kyun Park, "Bioprinting of heterogeneous and multilayered cell-hydrogel constructs using continuous multi-material printing and aerosol-based crosslinking," STAR Protocols, 3 (2), 101303 (2022).  OPEN ACCESS
External link
https://star-protocols.cell.com/protocols/1564
External link Supporting Information: Movie 1 (mp4, 39.8 MB), Movie 2 (mp4, 25.7 MB) 

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Soo Jee Kim, Gihyun Lee, Je-Kyun Park, "Direct microextrusion printing of a low viscosity hydrogel on a supportive microstructured bioprinting substrate for the vasculogenesis of endothelial cells," Adv. Mater. Technol., 7 (8), 2101326 (2022).
External link Supporting Info. (pdf, 940.9 KB), Supporting Movie 1 (mp4, 3.8 MB), and Movie 2 (mp4, 9.1 MB)

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Gihyun Lee, Soo Jee Kim, Honggu Chun, Je-Kyun Park, "Multilayered and heterogeneous hydrogel construct printing system with crosslinking aerosol," Biofabrication, 13 (4), 045027 (2021).   
External link Supporting Info.: Word (docx, 3.47 MB), Movie 1 (mp4, 1.08 MB) 

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Hyun Ji Gi, Dongsik Han, Je-Kyun Park, "Optoelectrofluidic printing system for fabricating hydrogel sheets with on-demand patterned cells and microparticles," Biofabrication, 9 (1), 015011 (2017).  
External link Supporting Info. (pdf, 320 KB), Video 1 (mp4, 1.05 MB), Video 2 (mp4, 1,68 MB)  

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Seung-Schik Yoo, Wonhye Lee, Je-Kyun Park, "Chapter 10. On-demand 3D freeform fabrication of tissue using bioprinting," In: F. Berthiaume and J. Morgan, editors. Methods in Bioengineering: 3D Tissue Engineering. Artech House; pp. 167-185, 2010.

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Wonhye Lee, Vivian Lee, Samuel Polio, Phillip Keegan, Jong-Hwan Lee, Krisztina Fischer, Je-Kyun Park, Seung-Schik Yoo, "On-demand three-dimensional freeform fabrication of multi-layered hydrogel scaffold with fluidic channels," Biotechnol. Bioeng., 105 (6), 1178-1186 (2010).

External link Selected as a Spotlight Article - 3D bio-printing of multi-layered cell-laden fluidic hydrogel scaffold

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Spotlight Article, "3D bio-printing of multi-layered cell-laden fluidic hydrogel scaffold" in Biotechnology and Bioengineering (2010, Volume 105, Issue 6)

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Wonhye Lee, Jason Pinckney, Vivian Lee, Jong-Hwan Lee, Krisztina Fischer, Samuel Polio, Je-Kyun Park, Seung-Schik Yoo, "Three-dimensional bioprinting of rat embryonic neural cells," NeuroReport, 20 (8), 798-803 (2009). External link Featured on the Front Cover Image

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Featured on the Front Cover Image of NeuroReport (May 27, 2009, Vol 20, Issue 8): Co-culture of bio-printed rat embryonic neurons and astrocytes in collagen matrix

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Wonhye Lee, Jason C. Debasitis, Vivian K. Lee, Jong-Hwan Lee, Krisztina Fischer, Karl Edminster, Je-Kyun Park, Seung-Schik Yoo, "Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication," Biomaterials, 30 (8), 1587-1595 (2009).