Research Highlights

Tissue & Organ Function-on-a-Chip

Related Articles:

29

Soo Jee Kim, Gihyun Lee, Je-Kyun Park, "Hybrid biofabrication of heterogeneous 3D constructs using low-viscosity bioinks," ACS Appl. Mater. Inter., 15 (35), 41247-41257 (2023).
External link Supporting Info. (pdf, Movie S1, Movie S2, and Movie S3)  

 28

Gihyun Lee, Soo Jee Kim, Je-Kyun Park, "Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip," Lab Chip, 23 (18), 4079-4091 (2023).
External link Supporting Info. (pdf, Video S1)  

27

Gihyun Lee, Soo Jee Kim, Je-Kyun Park, "Bioprinting of heterogeneous and multilayered cell-hydrogel constructs using continuous multi-material printing and aerosol-based crosslinking," STAR Protocols, 3 (2), 101303 (2022).   OPEN ACCESS
External link
https://star-protocols.cell.com/protocols/1564

26

Soo Jee Kim, Gihyun Lee, Je-Kyun Park, "Direct microextrusion printing of a low viscosity hydrogel on a supportive microstructured bioprinting substrate for the vasculogenesis of endothelial cells," Adv. Mater. Technol., 7 (8), 2101326 (2022).
External link Supporting Info. (pdf, 940.9 KB), Supporting Movie 1 (MP4, 3.8 MB), Movie 2 (MP4, 9.1 MB)

25

Hyewon Roh, Hwisoo Kim, Je-Kyun Park, "Construction of a fibroblast-associated tumor spheroid model based on a collagen drop array chip," Biosensors, 11 (12), 506 (2021).    OPEN ACCESS
External link Supporting Info. (pdf, 729 KB)

24

Minkyung Cho, Je-Kyun Park, "Modular 3D in vitro artery-mimicking multichannel system for recapitulating vascular stenosis and inflammation," Micromachines, 12 (12), 1528 (2021).    OPEN ACCESS
External link
Supporting Info. (pdf, 806 KB)

23

Gihyun Lee, Soo Jee Kim, Honggu Chun, Je-Kyun Park, "Multilayered and heterogeneous hydrogel construct printing system with crosslinking aerosol," Biofabrication, 13 (4), 045027 (2021).   
External link Supporting Info. (docx, 3.47 MB), Movie 1 (MP4, 1.08 MB)

22

Hwisoo Kim, Hyewon Roh, Haseong Kim, Je-Kyun Park, "Droplet contact-based spheroid transfer technique as a multi-step assay tool for spheroid arrays," Lab Chip, 21 (21), 4155-4165 (2021).  
External link Supporting Info. (PDF, 547 KB), Movie 1 (MP4, 3064 KB), Movie 2 (MP4, 5376 KB), Movie 3 (MP4, 540 KB)

21

Jaejung Son, Hee-Hoon Kim, Jun-Hee Lee, Won-Il Jeong, Je-Kyun Park, "Assembly and disassembly of the micropatterned collagen sheets containing cells for location-based cellular function analysis," BioChip J., 15 (1) 77-89 (2021).
External link Featured on the Cover Article     
External link Supporting Info. (docx, 1804 KB)

20

Featured on the Cover Article in BioChip Journal (Issue 1, 2021)

19

Haewon Seo, Jaejung Son, Je-Kyun Park, "Controlled 3D co-culture of beta cells and endothelial cells in a micropatterned collagen sheet for reproducible construction of an improved pancreatic pseudo-tissue," APL Bioeng., 4 (4), 046103 (2020).   OPEN ACCESS
External link The first two authors contributed equally to this work.

18

Minkyung Cho, Je-Kyun Park, "Fabrication of a perfusable 3D in vitro artery-mimicking multichannel system for artery disease models," ACS Biomater. Sci. Eng., 6 (9), 5326-5336 (2020).  
External link
Supporting Info. (pdf, 541 KB) 

17

Juhwan Park, Hwisoo Kim, Je-Kyun Park, "Microfluidic channel-integrated hanging drop array chip operated by pushbuttons for spheroid culture and analysis ," Analyst, 145 (21), 6974-6980 (2020).  
External link External link
Supporting Info. (pdf, 349 KB), Movie 1 (MP4, 273 KB)

16

Young Lee, Soo Jee Kim, Je-Kyun Park, "Chips-on-a-plate device for monitoring cellular migration in a microchannel-based intestinal follicle-associated epithelium model," Biomicrofluidics, 13 (6), 064127 (2019).  
External link Supporting Info. (DOCX, 273KB)

15

Young Lee, Gihyun Lee, Minkyung Cho, Je-Kyun Park, "Design criteria and standardization of a microfluidic cell culture system for investigating cellular migration," J. Micromech. Microeng., 29 (4), 043003 (2019).  
External link Invited Topical Review 

14

Jaejung Son, Min Seo Bang, Je-Kyun Park, "Hand-maneuverable collagen sheet with micropatterns for 3D modular tissue engineering," ACS Biomater. Sci. Eng., 5 (1), 339-345 (2019).  
External link Supporting Info. (pdf, 828 KB)

13

Simple devices enhance the embedment of spheroids into hydrogel arrays, AIP Scilight -- by Mary Alexandra Agner, Scilight 2018, 290005 (2018); https://doi.org/10.1063/1.5047432

12

Hwisoo Kim, Chang Hyun Cho, Je-Kyun Park, "High-throughput culture and embedment of spheroid array using droplet contact-based spheroid transfer," Biomicrofluidics, 12 (4), 044109 (2018).
External link Supporting Info. (doc, 3 MB, video MP4, 572 KB)
External link Featured Article (July 1, 2018)

External link Highlighted in AIP Scilight (Simple devices enhance the embedment of spheroids into hydrogel arrays --- by Mary Alexandra Agner)

11

Young Lee, Je-Kyun Park, "Microfabricated cell culture system for the live cell observation of the multilayered proliferation of undifferentiated HT-29 cells," BioChip J.11 (4), 308-315 (2017).

10

Chae Yun Bae, Jaejung Son, Hail Kim, Je-Kyun Park, "Demonstration of interposed modular hydrogel sheet for multicellular analysis in a microfluidic assembly platform," Sci. Rep., 7, 1289 (2017).      OPEN ACCESS  
External link Supporting Info. (pdf, 1.91 MB)

9

Chang Hyun Cho, Seyong Kwon, Je-Kyun Park, "Assembly of hydrogel units for 3D microenvironment in a poly(dimethylsiloxane) channel," Micro Nano Syst. Lett., 5, 2 (2017).    OPEN ACCESS  

8

Jaejung Son, Chae Yun Bae, Je-Kyun Park, "Construction of modular hydrogel sheets for micropatterned macro-scaled 3D cellular architecture," J. Vis. Exp., 107, e53475, doi:10.3791/53475 (2016).  

External link Materials List (pdf, 53.4 KB) 
External link video clip (MP4, 36.9 MB)
  

7

Commentary in Biotechnology Journal: Stackable micropatterned hydrogels for analysis of thick tissues in vitro by Bobak Mosadegh

External link See accompanying article by Son et al. DOI 10.1002/biot.201500384

6

Jaejung Son, Chae Yun Bae, Je-Kyun Park, "Freestanding stacked mesh-like hydrogel sheets enable the creation of complex macroscale cellular scaffolds," Biotechnol. J., 11 (4), 585-591 (2016).    
External link Supporting Info. (zip, 6661 KB)  

External link See accompanying commentary by Bobak Mosadegh DOI 10.1002/biot.201500562 

5

Chae Yun Bae, Moon-kyung Min, Hail Kim, Je-Kyun Park, "Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters," Lab Chip, 14 (13), 2183-2190 (2014).  

4

Wonhye Lee, Chae Yun Bae, Seyong Kwon, Jaejung Son, Jinho Kim, Yong Jeong, Seung-Schik Yoo, Je-Kyun Park, "Cellular hydrogel biopaper for patterned 3D cell culture and modular tissue reconstruction," Adv. Healthcare Mater.1 (5), 635-639 (2012).  
External link Supporting Info. (pdf, 366 KB; Video MP4, 305 KB)

3

Featured on the Inside Front Cover, Tissue Reconstruction (Adv. Healthcare Mater. 5/2012) (page 530)

2

Wonhye Lee, Jaejung Son, Seung-Schik Yoo, Je-Kyun Park, "Facile and biocompatible fabrication of chemically sol-gel transitional hydrogel free-standing microarchitectures," Biomacromolecules, 12 (1), 14-18 (2011).    
External link Supporting Info. (pdf, 828 KB)

1

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Joon Seok Lee, Eujin Um, Je-Kyun Park, Chan Beum Park, "Microfluidic self-assembly of insulin monomers into amyloid fibrils on a solid surface," Langmuir, 24 (14), 7068-7071 (2008).
External link Supporting Info. (pdf, 3.32 MB)