Research Highlights

 Sample Pretreatment and Detection

Related Articles:

40

Jieun Han, Hye Jin Lim, Juhwan Park, Dong Hyun Han, Dong-Myung Kim, Je-Kyun Park, "On-chip microfluidic dual detection of amino acid metabolism disorders using cell-free protein synthesis," Biosens. Bioelectron., 222, 114936 (2023).  
External link Supporting Info.: Video S1 (MP4, 4 MB)Word (docx, 8 MB) 

39

Hyewon Roh, Hwisoo Kim, Je-Kyun Park, "Construction of a fibroblast-associated tumor spheroid model based on a collagen drop array chip," Biosensors, 11 (12), 506 (2021).    OPEN ACCESS
External link Supporting Info. (pdf, 729 KB)

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Ariel J. Lee, Dongjo Yoon, SeungYoon Han, Herve Hugonnet, WeiSun Park, Je-Kyun Park, Yoonkey Nam, YongKeun Park, "Label-free monitoring of 3D cortical neuronal growth in vitro using optical diffraction tomography," Biomed. Opt. Express, 12 (11), 6928-6939 (2021).   OPEN ACCESS

37

Hwisoo Kim, Hyewon Roh, Haseong Kim, Je-Kyun Park, "Droplet contact-based spheroid transfer technique as a multi-step assay tool for spheroid arrays," Lab Chip, 21 (21), 4155-4165 (2021).  
External link Supporting Info. (PDF, 547 KB), Movie 1 (MP4, 3064 KB), Movie 2 (MP4, 5376 KB), Movie 3 (MP4, 540 KB)

36

Advances in design position push-button mechanisms for future use in biomicrofluidic applications -- by Adam Liebendorfer, Scilight, 2021, 281108 (2021); https://doi.org/10.1063/10.0005665

35

Juhwan Park, Je-Kyun Park, "Pushbutton-activated microfluidic cartridge as a user-friendly sample preparation tool for diagnostics," Biomicrofluidics, 15 (4), 041302 (2021).  
External link Invited Perspective
External link Featured Article (July 9, 2021)  
External link Highlighted in AIP Scilight (Advances in design position push-button mechanisms for future use in biomicrofluidic applications --- by Adam Liebendorfer)

34

Juhwan Park, Kyoung G. Lee, Dong Hyun Han, Ji-Soo Lee, Seok Jae Lee, Je-Kyun Park, "Pushbutton-activated microfluidic dropenser for droplet digital PCR," Biosens. Bioelectron., 181, 113159 (2021).  
External link Supporting Info.: Video S1 (MP4, 654 KB)Word (docx, 2MB)

33

Yoo Min Park, Juhwan Park, Sun Young Lim, Yeji Kwon, Nam Ho Bae, Je-Kyun Park, Seok Jae Lee, "Integrated pumpless microfluidic chip for the detection of foodborne pathogens by polymerase chain reaction and electrochemical analysis," Sens. Actuators B Chem., 329, 129130 (2021).  
External link The first two authors contributed equally to this work.  

32

Juhwan Park, Hwisoo Kim, Je-Kyun Park, "Microfluidic channel-integrated hanging drop array chip operated by pushbuttons for spheroid culture and analysis," Analyst, 145 (21), 6974-6980 (2020).  
External link
Supporting Info. (pdf, 349 KB), Movie 1 (MP4, 273 KB)

31

Juhwan Park, Dong Hyun Han, Sang-Hyun Hwang, Je-Kyun Park, "Reciprocating flow-assisted nucleic acid purification using a finger-actuated microfluidic device," Lab Chip, 20 (18), 3346-3353 (2020). 
External link The first two authors contributed equally to this work.  
External link Supporting Info. Movie 1 (MP4, 2535 KB), Movie 2 (MP4, 2829 KB)

30

Chi Hyun Kim, Juhwan Park, Soo Jee Kim, Dae-Hyun Ko, Song Ha Lee, Seok Jae Lee, Je-Kyun Park, Moon-Keun Lee, "On-site extraction and purification of bacterial nucleic acids from blood samples using an unpowered microfluidic device," Sens. Actuators B Chem., 320, 128346 (2020).
External link The first two authors contributed equally to this work.  
External link Supporting Info. (docx, 44 KB)   

29

Younggeun Jo, Juhwan Park, Je-Kyun Park, "Colorimetric detection of Escherichia coli O157:H7 with signal enhancement using size-based filtration on a finger-powered microfluidic device," Sensors, 20 (8) 2267 (2020).    OPEN ACCESS
External link The first two authors contributed equally to this work.

28

Inside Back Cover of Lab on a Chip (Issue 7, 2020): Critical review of user-friendly microfluidic devices towards practical sample preparation in point-of-care-testing, which can facilitate mixing of multiple reagents, effective reaction between biomolecules, separation of target particles, and compartmentalization for high-throughput or digital analysis.

27

Juhwan Park, Dong Hyun Han, Je-Kyun Park, "Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices," Lab Chip, 20 (7), 1191-1203 (2020).  
External link Critical Review  
External link Featured on the Inside Back Cover Article  

26

Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic display for smart blood typing," Anal. Chem., 91 (18), 11636-11642 (2019).  
External link
Supporting Info. (pdf, 1.32 MB), Movie (MP4, 429 KB)

25

Juhwan Park, Hyewon Roh, Je-Kyun Park, "Finger-actuated microfluidic concentration gradient generator compatible with a microplate," Micromachines, 10 (3), 174 (2019).  OPEN ACCESS
External link The first two authors contributed equally to this work.

24

Seonhee Lee, Juhwan Park, Je-Kyun Park, "Foldable paper-based analytical device for the detection of an acetylcholinesterase inhibitor using an angle-based readout," Sens. Actuators B Chem., 273, 322-327 (2018).

23

Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic device for the blood-cross matching test," Lab Chip, 18 (8), 1215-1222 (2018).
External link Supporting Info. (pdf, 526 KB) 

22

Joong Ho Shin, Jisoo Hong, Hyeyun Go, Juhwan Park, Minsuk Kong, Sangryeol Ryu, Kwang-Pyo Kim, Eunjung Roh, Je-Kyun Park, "Multiplexed detection of foodborne pathogens from contaminated lettuces using a handheld multistep lateral flow assay device," J. Agric. Food Chem., 66 (1), 290-297 (2018).   
External link The first two authors contributed equally to this work.
External link Supporting Info. (pdf, 194.55 KB)

21

GwangSik Park, Dongsik Han, GwangSu Kim, Seungwoo Shin, Kyoohyun Kim, Je-Kyun Park, YongKeun Park, "Visualization and label-free quantification of microfluidic mixing using quantitative phase imaging," Appl. Optics, 56 (22), 6341-6347 (2017).  
External link The first three authors contributed equally to this work.

20

Jae Hoon Oh, Moon Kyoo Park, Seong Wook Kim, Je-Kyun Park, "A fully automated analyzer for multiple detection of allergen-specific immunoglobulin E," Anal. Methods, 7 (20), 8889-8895 (2015).

19

Do-Hyun Lee, Miran Jang, Je-Kyun Park, "Rapid one-step purification of single-cells encapsulated in alginate microcapsules from oil to aqueous phase using a hydrophobic filter paper: Implications for single-cell experiments," Biotechnol. J., 9 (10), 1233-1240 (2014).  
External link Supporting Info. (pdf, 361 KB)

18

Jung Kim, Seyong Kwon, Je-Kyun Park, Inkyu Park, "Quantum dot-based immunoassay enhanced by high-density vertical ZnO nanowire array," Biosens. Bioelectron., 55, 209-215 (2014).    
External link The first two authors contributed equally to this work
Supporting Info. (docx, 3,133 KB)

17

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Dae-Sik Lee, Byoung Gu Jeon, Chunhwa Ihm, Je-Kyun Park, Mun Yeon Jung, "A simple and smart telemedicine device for developing regions: a pocket-sized colorimetric reader," Lab Chip, 11 (1), 120-126 (2011).    
External link Supporting Info. (pdf, 331 KB) and Movie (MP4, 8.63 MB)
External link Lab on a Chip Blog: Medicine gets smart (2010. 11. 26)  
External link Selected for Vir. J. Bio. Phys. Res. (2010)/ Volume 20 / Issue 12 / INSTRUMENTATION DEVELOPMENT (2010. 12. 15)

16

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Sungyoung Choi, Myung Gwon Lee, Je-Kyun Park, "Microfluidic parallel circuit for measurement of hydraulic resistance," Biomicrofluidics, 4 (3), 034110 (2010).  

15

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Sungyoung Choi, Je-Kyun Park, "Microfluidic rheometer for characterization of protein unfolding and aggregation in microflows," Small, 6 (12), 1306-1310 (2010).  

14

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Jaeduck Jang, Chae Yun Bae, Je-Kyun Park, Jong Chul Ye, "Self-reference quantitative phase microscopy for microfluidic devices," Opt. Lett., 35 (4), 514-516 (2010). 
External link Selected for Vir. J. Biomed. Opt. (2010)/ Volume 5 / Issue 5 / Microfluidics and Nanofluidics
External link Selected for Vir. J. Bio. Phys. Res. (2010)/ Volume 19 / Issue 6 / INSTRUMENTATION DEVELOPMENT (2010. 3. 15)

13

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Sungyoung Choi, Seung-Hoon Kim, Je-Kyun Park, "Optical path-length modulation for three-dimensional particle measurement in mirror-embedded microchannels," Lab Chip, 10 (3), 335-340 (2010).

12

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Joo H. Kang, Bumjun Kim, Je-Kyun Park, "Microfluidic pycnometer for in situ analysis of fluids in microchannels," Anal. Chem., 81 (7), 2569-2574 (2009).    
External link Supporting Info. (pdf, 232 KB) & Movie (avi, 2.54 MB)

11

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Sungyoung Choi, Je-Kyun Park, "Mirror-embedded microchannel for three-dimensional measurement of particle position," Appl. Phys. Lett., 93 (19), 191909 (2008).
External link Supporting Info. (pdf, 197.9 KB)

10

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Sungho Ko, Bumjun Kim, Seong-Sik Jo, Se Young Oh, Je-Kyun Park, "Electrochemical detection of cardiac troponin I using a microfluidic chip with the surface-functionalized poly(dimethylsiloxane) channel," Biosens. Bioelectron., 23 (1), 51-59 (2007).

9

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Jeong-Gun Lee, Kyusik Yun, Guei-Sam Lim, Sang Eun Lee, Suhyeon Kim, Je-Kyun Park, "DNA biosensor based on the electrochemiluminescence of Ru(bpy)32+ with DNA-binding intercalators," Bioelectrochemistry, 70 (2), 228-234 (2007).

8

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Yoonhee Jang, Se Young Oh, Je-Kyun Park, "In situ electrochemical enzyme immunoassay on a microchip with surface-functionalized poly(dimethylsiloxane) channel," Enzyme Microb. Technol., 39 (5), 1122-1127 (2006).

7

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Suhyeon Kim, Guei-Sam Lim, Sang Eun Lee, Jeong-Gun Lee, Kyusik Yun, Je-Kyun Park, "DNA chip replication for a personalized DNA chip," Biomol. Eng., 23 (2-3), 129-134 (2006).

6

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Wonjae Choi, Je-Kyun Park, "A bio-fluidic device for adaptive sample pretreatment and its application to measurement of Escherichia coli concentration," Biotechnol. Bioprocess Eng., 11 (1), 54-60 (2006).

5

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Sungyoung Choi, Je-Kyun Park, "Microfluidic system for dielectrophoretic separation based on a trapezoidal electrode array," Lab Chip, 5 (10), 1161-1167 (2005).  
External link Spporting Info.: Video 0 (Fig.3a), Video 1 (Fig. 5a), Video 2 (Fig. 5b), Video 3 (Fig. 5c)

4

 Joo H. Kang, Je-Kyun Park, "Development of a microplate reader compatible microfluidic device for enzyme assay," Sens. Actuators B Chem., 107 (2), 980-985 (2005).

3

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Ju Hun Yeon, Je-Kyun Park, "Cytotoxicity test based on electrochemical impedance measurement of HepG2 cultured in microfabricated cell chip," Anal. Biochem., 341 (2), 308-315 (2005).
External link Selected in National Cancer Institute (NCI) Nanotech News (May 23, 2005)

2

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Yuheon Yi, Je-Kyun Park, "Fabrication of electrochemical sensor with tunable electrode distance," J. Semiconductor Technol. Sci., 5 (1), 30-37 (2005).  

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Suhyeon Kim, Je-Kyun Park, "Development of a test strip reader for a lateral flow membrane-based immunochromatographic assay," Biotechnol. Bioprocess Eng., 9 (2), 127-131 (2004).