Research Highlights

 Sample Pretreatment and Detection

Related Articles:


Juhwan Park, Hwisoo Kim, Je-Kyun Park, "Microfluidic channel-integrated hanging drop array chip operated by pushbuttons for spheroid culture and analysis," Analyst, in press (2020).
External link
Supporting Info. (pdf, 349 KB), Movie 1 (MP4, 273 KB)


Juhwan Park, Dong Hyun Han, Sang-Hyun Hwang, Je-Kyun Park, "Reciprocating flow-assisted nucleic acid purification using a finger-actuated microfluidic device," Lab Chip, 20 (18), 3346-3353 (2020). 
The first two authors contributed equally to this work.
External link Supporting Info. Movie 1 (MP4, 2535 KB), Movie 2 (MP4, 2829 KB)


Chi Hyun Kim, Juhwan Park, Soo Jee Kim, Dae-Hyun Ko, Song Ha Lee, Seok Jae Lee, Je-Kyun Park, Moon-Keun Lee, "On-site extraction and purification of bacterial nucleic acids from blood samples using an unpowered microfluidic device," Sens. Actuators B Chem., 320, 128346 (2020).
The first two authors contributed equally to this work.
External link Supporting Info. (docx, 44 KB)   


Younggeun Jo, Juhwan Park, Je-Kyun Park, "Colorimetric detection of Escherichia coli O157:H7 with signal enhancement using size-based filtration on a finger-powered microfluidic device," Sensors, 20 (8) 2267 (2020).    OPEN ACCESS
The first two authors contributed equally to this work.


Inside Back Cover of Lab on a Chip (Issue 7, 2020): Critical review of user-friendly microfluidic devices towards practical sample preparation in point-of-care-testing, which can facilitate mixing of multiple reagents, effective reaction between biomolecules, separation of target particles, and compartmentalization for high-throughput or digital analysis.


Juhwan Park, Dong Hyun Han, Je-Kyun Park, "Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices," Lab Chip, 20 (7), 1191-1203 (2020).  
External link Critical Review  
External link Featured on the Inside Back Cover Article  


Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic display for smart blood typing," Anal. Chem., 91 (18), 11636-11642 (2019).  
External link
Supporting Info. (pdf, 1.32 MB), Movie (MP4, 2.12 MB)


Juhwan Park, Hyewon Roh, Je-Kyun Park, "Finger-actuated microfluidic concentration gradient generator compatible with a microplate," Micromachines, 10 (3), 174 (2019).  OPEN ACCESS
The first two authors contributed equally to this work.


Seonhee Lee, Juhwan Park, Je-Kyun Park, "Foldable paper-based analytical device for the detection of an acetylcholinesterase inhibitor using an angle-based readout," Sens. Actuators B Chem., 273, 322-327 (2018).


Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic device for the blood-cross matching test," Lab Chip, 18 (8), 1215-1222 (2018).
External link Supporting Info. (pdf, 526 KB) 


Joong Ho Shin, Jisoo Hong, Hyeyun Go, Juhwan Park, Minsuk Kong, Sangryeol Ryu, Kwang-Pyo Kim, Eunjung Roh, Je-Kyun Park, "Multiplexed detection of foodborne pathogens from contaminated lettuces using a handheld multistep lateral flow assay device," J. Agric. Food Chem., 66 (1), 290-297 (2018).   The first two authors contributed equally to this work.
External link Supporting Info. (pdf, 194.55 KB)


GwangSik Park, Dongsik Han, GwangSu Kim, Seungwoo Shin, Kyoohyun Kim, Je-Kyun Park, YongKeun Park, "Visualization and label-free quantification of microfluidic mixing using quantitative phase imaging," Appl. Optics, 56 (22), 6341-6347 (2017).   The first three authors contributed equally to this work.


Jae Hoon Oh, Moon Kyoo Park, Seong Wook Kim, Je-Kyun Park, "A fully automated analyzer for multiple detection of allergen-specific immunoglobulin E," Anal. Methods, 7 (20), 8889-8895 (2015).


Do-Hyun Lee, Miran Jang, Je-Kyun Park, "Rapid one-step purification of single-cells encapsulated in alginate microcapsules from oil to aqueous phase using a hydrophobic filter paper: Implications for single-cell experiments," Biotechnol. J., 9 (10), 1233-1240 (2014).  
External link Supporting Info. (pdf, 361 KB)


Jung Kim, Seyong Kwon, Je-Kyun Park, Inkyu Park, "Quantum dot-based immunoassay enhanced by high-density vertical ZnO nanowire array," Biosens. Bioelectron., 55, 209-215 (2014).    The first two authors contributed equally to this work
Supporting Info. (docx, 3,133 KB)



Dae-Sik Lee, Byoung Gu Jeon, Chunhwa Ihm, Je-Kyun Park, Mun Yeon Jung, "A simple and smart telemedicine device for developing regions: a pocket-sized colorimetric reader," Lab Chip, 11 (1), 120-126 (2011).    
External link Supporting Info. (pdf, 331 KB) and Movie (wmv, 17.9 MB)
External link Lab on a Chip Blog: Medicine gets smart (2010. 11. 26)  
External link Selected for Vir. J. Bio. Phys. Res. (2010)/ Volume 20 / Issue 12 / INSTRUMENTATION DEVELOPMENT (2010. 12. 15)



Sungyoung Choi, Myung Gwon Lee, Je-Kyun Park, "Microfluidic parallel circuit for measurement of hydraulic resistance," Biomicrofluidics, 4 (3), 034110 (2010).  



Sungyoung Choi, Je-Kyun Park, "Microfluidic rheometer for characterization of protein unfolding and aggregation in microflows," Small, 6 (12), 1306-1310 (2010).  



Jaeduck Jang, Chae Yun Bae, Je-Kyun Park, Jong Chul Ye, "Self-reference quantitative phase microscopy for microfluidic devices," Opt. Lett., 35 (4), 514-516 (2010). 
External link Selected for Vir. J. Biomed. Opt. (2010)/ Volume 5 / Issue 5 / Microfluidics and Nanofluidics
External link Selected for Vir. J. Bio. Phys. Res. (2010)/ Volume 19 / Issue 6 / INSTRUMENTATION DEVELOPMENT (2010. 3. 15)



Sungyoung Choi, Seung-Hoon Kim, Je-Kyun Park, "Optical path-length modulation for three-dimensional particle measurement in mirror-embedded microchannels," Lab Chip, 10 (3), 335-340 (2010).



Joo H. Kang, Bumjun Kim, Je-Kyun Park, "Microfluidic pycnometer for in situ analysis of fluids in microchannels," Anal. Chem., 81 (7), 2569-2574 (2009).    
External link Supporting Info. (pdf, 232 KB) & Movie (avi, 2.54 MB)



Sungyoung Choi, Je-Kyun Park, "Mirror-embedded microchannel for three-dimensional measurement of particle position," Appl. Phys. Lett., 93 (19), 191909 (2008).
External link Supporting Info. (pdf, 197.9 KB)



Sungho Ko, Bumjun Kim, Seong-Sik Jo, Se Young Oh, Je-Kyun Park, "Electrochemical detection of cardiac troponin I using a microfluidic chip with the surface-functionalized poly(dimethylsiloxane) channel," Biosens. Bioelectron., 23 (1), 51-59 (2007).



Jeong-Gun Lee, Kyusik Yun, Guei-Sam Lim, Sang Eun Lee, Suhyeon Kim, Je-Kyun Park, "DNA biosensor based on the electrochemiluminescence of Ru(bpy)32+ with DNA-binding intercalators," Bioelectrochemistry, 70 (2), 228-234 (2007).



Yoonhee Jang, Se Young Oh, Je-Kyun Park, "In situ electrochemical enzyme immunoassay on a microchip with surface-functionalized poly(dimethylsiloxane) channel," Enzyme Microb. Technol., 39 (5), 1122-1127 (2006).



Suhyeon Kim, Guei-Sam Lim, Sang Eun Lee, Jeong-Gun Lee, Kyusik Yun, Je-Kyun Park, "DNA chip replication for a personalized DNA chip," Biomol. Eng., 23 (2-3), 129-134 (2006).



Wonjae Choi, Je-Kyun Park, "A bio-fluidic device for adaptive sample pretreatment and its application to measurement of Escherichia coli concentration," Biotechnol. Bioprocess Eng., 11 (1), 54-60 (2006).



Sungyoung Choi, Je-Kyun Park, "Microfluidic system for dielectrophoretic separation based on a trapezoidal electrode array," Lab Chip, 5 (10), 1161-1167 (2005).  
External link Spporting Info. (mpg movie 1, 2, 3)


 Joo H. Kang, Je-Kyun Park, "Development of a microplate reader compatible microfluidic device for enzyme assay," Sens. Actuators B Chem., 107 (2), 980-985 (2005).



Ju Hun Yeon, Je-Kyun Park, "Cytotoxicity test based on electrochemical impedance measurement of HepG2 cultured in microfabricated cell chip," Anal. Biochem., 341 (2), 308-315 (2005).
External link Selected in National Cancer Institute (NCI) Nanotech News (May 23, 2005)



Yuheon Yi, Je-Kyun Park, "Fabrication of electrochemical sensor with tunable electrode distance," J. Semiconductor Technol. Sci., 5 (1), 30-37 (2005).  



Suhyeon Kim, Je-Kyun Park, "Development of a test strip reader for a lateral flow membrane-based immunochromatographic assay," Biotechnol. Bioprocess Eng., 9 (2), 127-131 (2004).