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Optoelectrofluidic Manipulation & Detection Optoelectrofluidic technology allows programmable manipulation of particles or fluids in microenvironments based on optically induced electrokinetics resulted from photochemical, photoconductive, and photothermal effects [Lab Chip 2011, 11, 2518]. Based on the electrokinetic motion of particles or fluid under an electric field induced by light, an image-based manipulation of several biological materials, including blood cells [Electrophoresis 2008, 29, 1203], oocytes [Biomicrofluidics 2009, 3, 014103], swimming bacteria [Appl. Phys. Lett. 2008, 93, 143901], as well as separation and assembly of colloidal particles [Langmuir 2009, 25, 6010] has been demonstrated. Recently, our group demonstrated a rapid and selective concentration of microparticles by combining several electrokinetic mechanisms, including ac electroosmosis and dielectrophoresis, and electrostatic interactions [Lab Chip 2009, 9, 199]. The particle movements resulted from the frequency-dependent behavior according to the particle diameter. The dynamic control of local molecular concentration was also achieved by using several frequency-dependent optoelectrofluidic phenomena [Anal. Chem. 2009, 81, 5865]. This new platform could be applied to develop an integrated system for optoelectrofluidic manipulation of micro- and nanoparticles including living cells and biomolecules [Adv. OptoElectronics 2011, 2011, Article ID 482483]. Recently we report a new kind of optoelectrofluidic sandwich immunoassay scheme based on the optoelectrofluidic device coupled with conventional surface-enhanced Raman scattering (SERS) setup [Anal. Chem. 2010, 82, 7603]. This image-driven immunoassay platform as well as optoelectrofluidic SERS spectroscopy [Lab Chip 2011, 11, 2518] opens a new way for simple, fast, automated, and highly sensitive detection of antigens without any washing steps. Related Articles: |
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Hyun
Ji Gi, Dongsik Han, Je-Kyun Park, "Optoelectrofluidic printing system for
fabricating hydrogel sheets with on-demand patterned cells and microparticles," Biofabrication, 9
(1),
015011 (2017).
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24 |
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This paper from researchers at KAIST presents a microarray-integrated optoelectrofluidic immunoassay system to overcome a diffusion limitation problem of conventional methods under static environments that cause low reaction efficiency. Optically-induced AC electroosmotic flows actively enhanced the mass transport of molecules at the multiple assay spots of the microarray simultaneously, which reduced reaction times. |
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Dongsik
Han, Je-Kyun Park, "Microarray-integrated optoelectrofluidic immunoassay
system," Biomicrofluidics, 10 (3), 034106 (2016).
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22 |
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Dongsik
Han, Je-Kyun Park, "Optoelectrofluidic enhanced immunoreaction based on
optically-induced dynamic AC electroosmosis," Lab Chip, 16
(7), 1189-1196 (2016). |
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21 |
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Dongsik
Han, Hyundoo Hwang, Je-Kyun Park, "Optoelectrofluidic behavior of metal-polymer
hybrid colloidal particles," Appl. Phys. Lett.,
102 (5), 054105 (2013). |
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20 |
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Hyundoo Hwang, Je-Kyun
Park, "Optoelectrofluidic manipulation of nanoparticles and biomolecules,
Adv. OptoElectronics, 2011, Article ID 482483, 13 pages (2011).
doi:10.1155/2011/482483 OPEN
ACCESS |
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19 |
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Hyundoo Hwang, Dongsik
Han, Young-Jae Oh, Yoon-Kyoung Cho, Ki-Hun Jeong, Je-Kyun Park, "In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic
SERS platform," Lab
Chip, 11 (15), 2518-2555 (2011). |
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18 |
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Hyundoo Hwang, Je-Kyun Park, "Optoelectrofluidic
platforms for chemistry and biology," Lab Chip, 11
(1), 33-47 (2011). |
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17 |
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Hyundoo Hwang, Hyangah
Chon, Jaebum Choo, Je-Kyun Park, "Optoelectrofluidic sandwich immunoassays for
detection of human tumor marker using surface-enhanced Raman scattering," Anal.
Chem., 82
(18), 7603-7610 (2010). |
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Hyundoo Hwang, Je-Kyun Park, "Programmable cell manipulation using lab-on-a-display," In: S. Kakaç, B. Kosoy, D. Li, A. Pramuanjaroenkij (eds). Microfluidics Based Microsystems: Fundamentals and Applications (NATO Science for Peace and Security Series A: Chemistry and Biology). Springer; pp. 595-613, 2010. |
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From Wikipedia, the free encyclopedia:
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14 |
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Hyundoo Hwang, Je-Kyun
Park, "Measurement
of molecular diffusion based on optoelectrofluidic fluorescence microscopy,"
Anal.
Chem., 81 (21), 9163-9167 (2009).
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13 |
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Do-Hyun Lee, Hyundoo
Hwang, Je-Kyun Park,
"Generation and manipulation of droplets in an
optoelectrofluidic device integrated with
microfluidic channels," Appl. Phys.
Lett., 95 (16), 164102 (2009).
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12 |
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Hyundoo Hwang, Je-Kyun
Park, "Dynamic
light-activated control of local chemical concentration in a fluid," Anal.
Chem., 81 (14),
5865-5870 (2009).
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11 |
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Hyundoo Hwang, Youn-Hee
Park, Je-Kyun Park, "Optoelectrofluidic control of colloidal assembly in
an optically induced electric field," Langmuir,
25 (11), 6010-6014 (2009). |
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10 |
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Hyundoo Hwang, Do-Hyun
Lee, Wonjae Choi, Je-Kyun Park, "Enhanced discrimination of normal oocytes using
optically induced pulling-up dielectrophoretic
force," Biomicrofluidics,
3 (1), 014103
(2009). |
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YouTube Video related to research article in Lab on a chip, "Rapid and selective concentration of microparticles in an optoelectrofluidic platform Read article" |
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8 |
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Hyundoo
Hwang, Je-Kyun Park, "Rapid and selective concentration of
microparticles in an optoelectrofluidic platform," Lab
Chip,
9 (2), 199-206
(2009).
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7 |
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Wonjae
Choi, Seong-Won Nam, Hyundoo Hwang, Sungsu Park, Je-Kyun Park,
"Programmable manipulation of motile cells in
optoelectronic tweezers using a grayscale
image," Appl. Phys. Lett.,
93 (14), 143901 (2008).
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6 |
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Hyundoo
Hwang, Jae-Jun Kim, Je-Kyun Park, "Experimental
investigation of electrostatic particle-particle interactions
in optoelectronic tweezers," J. Phys. Chem.
B, 112 (32), 9903-9908 (2008).
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5 |
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Hyundoo
Hwang, Yong-Je Choi, Wonjae Choi, Se-Hwan Kim, Jin Jang,
Je-Kyun Park, "Interactive manipulation of blood cells using a
lens-integrated liquid crystal display based optoelectronic
tweezers system," Electrophoresis, 29
(6), 1203-1212 (2008).
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Hyundoo Hwang, Youngjae Oh, Jae-Jun Kim, Wonjae Choi, Je-Kyun Park, Se-Hwan Kim, Jin Jang, "Reduction of nonspecific surface-particle interactions in optoelectronic tweezers," Appl. Phys. Lett., 92 (2), 024108 (2008). |
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Cover image in
BioChip Journal (2008,
Vol.2, No.1): Special Issue on "Lab-on-a-Chip" in BioChip Journal
(Edited by Je-Kyun Park) |
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Hyundoo Hwang, Youngjae Oh, Jae-Jun Kim, Wonjae Choi, Se-Hwan Kim, Jin Jang, Je-Kyun Park, "Optoelectronic manipulation of microparticles using double photoconductive layers on a liquid crystal display," Biochip J., 1 (4), 234-240 (2007). |
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1 |
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Wonjae
Choi, Se-Hwan Kim, Jin Jang, Je-Kyun Park, "Lab-on-a-display: a new microparticle manipulation platform
using a liquid crystal display (LCD)," Microfluid.
Nanofluid., 3 (2), 217-225 (2007). |
