Research Highlights

Microfluidic Point-of-Care Testing (POCT) Devices

Related Articles:

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Jieun Han, Hye Jin Lim, Juhwan Park, Dong Hyun Han, Dong-Myung Kim, Je-Kyun Park, "On-chip microfluidic dual detection of amino acid metabolism disorders using cell-free protein synthesis," Biosens. Bioelectron., 222, 114936 (2023).  
External link Supporting Info.: Video S1 (MP4, 4 MB)Word (docx, 8 MB) 

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Advances in design position push-button mechanisms for future use in biomicrofluidic applications -- by Adam Liebendorfer, Scilight, 2021, 281108 (2021); https://doi.org/10.1063/10.0005665

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Juhwan Park, Je-Kyun Park, "Pushbutton-activated microfluidic cartridge as a user-friendly sample preparation tool for diagnostics," Biomicrofluidics, 15 (4), 041302 (2021).  
External link Invited Perspective
External link Featured Article (July 9, 2021)  
External link Highlighted in AIP Scilight (Advances in design position push-button mechanisms for future use in biomicrofluidic applications --- by Adam Liebendorfer)

21

Yoo Min Park, Juhwan Park, Sun Young Lim, Yeji Kwon, Nam Ho Bae, Je-Kyun Park, Seok Jae Lee, "Integrated pumpless microfluidic chip for the detection of foodborne pathogens by polymerase chain reaction and electrochemical analysis," Sens. Actuators B Chem., 329, 129130 (2021).  
External link The first two authors contributed equally to this work.  

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Juhwan Park, Dong Hyun Han, Sang-Hyun Hwang, Je-Kyun Park, "Reciprocating flow-assisted nucleic acid purification using a finger-actuated microfluidic device," Lab Chip, 20 (18), 3346-3353 (2020).   
External link The first two authors contributed equally to this work.  
External link Supporting Info. Movie 1 (MP4, 2535 KB), Movie 2 (MP4, 2829 KB)

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Chi Hyun Kim, Juhwan Park, Soo Jee Kim, Dae-Hyun Ko, Song Ha Lee, Seok Jae Lee, Je-Kyun Park, Moon-Keun Lee, "On-site extraction and purification of bacterial nucleic acids from blood samples using an unpowered microfluidic device," Sens. Actuators B Chem., 320, 128346 (2020).
External link The first two authors contributed equally to this work.
External link Supporting Info. (docx, 44 KB)  

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Younggeun Jo, Juhwan Park, Je-Kyun Park, "Colorimetric detection of Escherichia coli O157:H7 with signal enhancement using size-based filtration on a finger-powered microfluidic device," Sensors, 20 (8) 2267 (2020).    OPEN ACCESS
External link The first two authors contributed equally to this work.

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Inside Back Cover of Lab on a Chip (Issue 7, 2020): Critical review of user-friendly microfluidic devices towards practical sample preparation in point-of-care-testing, which can facilitate mixing of multiple reagents, effective reaction between biomolecules, separation of target particles, and compartmentalization for high-throughput or digital analysis.

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Juhwan Park, Dong Hyun Han, Je-Kyun Park, "Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices," Lab Chip, 20 (7), 1191-1203 (2020).  
External link Critical Review 
External link Featured on the Inside Back Cover Article  

15

Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic display for smart blood typing," Anal. Chem., 91 (18), 11636-11642 (2019).  
External link
Supporting Info. (pdf, 1.32 MB), Movie (MP4, 429 KB)

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Juhwan Park, Je-Kyun Park, "Integrated microfluidic pumps and valves operated by finger actuation," Lab Chip, 19 (18), 2973-2977 (2019).  
External link
Supporting Info. (pdf, 291 KB), Movie (MP4, 1491 KB)

13

Seonhee Lee, Juhwan Park, Je-Kyun Park, "Foldable paper-based analytical device for the detection of an acetylcholinesterase inhibitor using an angle-based readout," Sens. Actuators B Chem., 273, 322-327 (2018).

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Juhwan Park, Je-Kyun Park, "Finger-actuated microfluidic device for the blood-cross matching test," Lab Chip, 18 (8), 1215-1222 (2018).
External link Supporting Info. (pdf, 526 KB) 

11

Joong Ho Shin, Jisoo Hong, Hyeyun Go, Juhwan Park, Minsuk Kong, Sangryeol Ryu, Kwang-Pyo Kim, Eunjung Roh, Je-Kyun Park, "Multiplexed detection of foodborne pathogens from contaminated lettuces using a handheld multistep lateral flow assay device," J. Agric. Food Chem., 66 (1), 290-297 (2018).  
External link The first two authors contributed equally to this work.
External link Supporting Info. (pdf, 194.55 KB)

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Minsuk Kong, Joong Ho Shin, Sunggi Heu, Je-Kyun Park, Sangryeol Ryu, "Lateral flow assay-based bacterial detection using engineered cell wall binding domains of a phage endolysin," Biosens. Bioelectron.,  96, 173-177 (2017).  
External link The first two authors contributed equally to this work.
External link
Supporting Info. (docx, 1.68 MB)

9

Juhwan Park, Je-Kyun Park, "Pressed region integrated 3D paper-based microfluidic device that enables vertical flow multistep assays for the detection of C-reactive protein based on programmed reagent loading," Sens. Actuators B Chem., 246, 1049-1055 (2017).
External link Supporting Info. (doc, 991 KB) 

8

Joong Ho Shin, Je-Kyun Park, "Functional packaging of lateral flow strip allows simple delivery of multiple reagents for multistep assays," Anal. Chem., 88 (21), 10374-10378 (2016).  
External link Supporting Info. (pdf, 1.85 MB)  

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ACS News Service Weekly PressPac: Wed Apr 06 05:31:00 EDT 2016 Paper-based test could help prevent food poisoning

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Juhwan Park, Joong Ho Shin, Je-Kyun Park, "Pressed paper-based dipstick for detection of foodborne pathogens with multistep reactions," Anal. Chem., 88 (7), 3781-3788 (2016).
External link Supporting Info. (pdf, 864 KB) 

External link Highlighted in the ACS News Service Weekly PressPac (2016. 4. 6)

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Dae-Sik Lee, Byoung Gu Jeon, Chunhwa Ihm, Je-Kyun Park, Mun Yeon Jung, "A simple and smart telemedicine device for developing regions: a pocket-sized colorimetric reader," Lab Chip, 11 (1), 120-126 (2011).    
External link Supporting Info. (pdf, 331 KB) and Movie (MP4, 8.63 MB)
External link Lab on a Chip Blog: Medicine gets smart (2010. 11. 26)  
External link Selected for Vir. J. Bio. Phys. Res. (2010)/ Volume 20 / Issue 12 / INSTRUMENTATION DEVELOPMENT (2010. 12. 15)

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Sungho Ko, Bumjun Kim, Seong-Sik Jo, Se Young Oh, Je-Kyun Park, "Electrochemical detection of cardiac troponin I using a microfluidic chip with the surface-functionalized poly(dimethylsiloxane) channel," Biosens. Bioelectron., 23 (1), 51-59 (2007).

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Yoonhee Jang, Se Young Oh, Je-Kyun Park, "In situ electrochemical enzyme immunoassay on a microchip with surface-functionalized poly(dimethylsiloxane) channel," Enzyme Microb. Technol., 39 (5), 1122-1127 (2006).

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Suhyeon Kim, Je-Kyun Park, "Development of a test strip reader for a lateral flow membrane-based immunochromatographic assay," Biotechnol. Bioprocess Eng., 9 (2), 127-131 (2004).

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Kang Shin Lee, Tae-Han Kim, Min-Chol Shin, Won-Yong Lee, Je-Kyun Park, "Disposable liposome immunosensor for theophylline combining an immunochromatographic membrane and a thick-film electrode," Anal. Chim. Acta., 380 (1), 17-26 (1999).